2, 2-bis(trifluoromethyl)-1, 3-dioxolane as inhalation anesthetic



United States Patent 3,314,850 2,2-BIS(TRIFLUOROMETHYL)-1,3-DIOXOLANE AS INHALATION ANESTHETIC Everett E. Gilbert, Morristown, N.J., assignor to Allied Chemical Corporation, New York, N.Y., a corporation of New York No Drawing. Filed Sept. 17, 1965, Ser. No. 488,240

Claim. (Cl. 167-52) This invention relates to a process for using 2,2-bis (trifluoromethyl)-l,3-dioxolane as a general inhalation anesthetic.

In the field of general anesthesia, many of the commonly used has high potency as a general inhalation anesthetic when administered to inhalation-anesthetic-susceptible organisrns.

3,314,850 Patented Apr. 18, 1967 of the mice).

The AD obtained upon testing the 2,2-bis(trifiuoromethyl)-l,3-dioxolane was 0.50, and the LD obtained was 2.38. The AI (anesthetic index=LD +AD was,

therefore, 4.7. The AI is a measure The three most highly commercial fiuorinated anesthetics (Fluomar isopropyl vinyl ether); Fluothane bromo-Z-chloroethane); Penthrane difluoroethyl ether)) have AD values 0.51 respectively, and AI values in the developed (triiiuoro- (1,1,.1-trifluoro-2- (2,2-dichloro-l,1- of 3.5, 0.78 and very low toxicity.

While the above describes the preferred embodiments I claim:

The process which comprises administering 2,2-bis(trifluoromethyl)-1,3-dioxolane as a general inhalation anesthetic to inhalation-anesthetic-susceptible organisms.

References Cited by the Examiner Chemical Abstracts 54, 21l01b-2l103a (1960).

ALBERT T. MEYERS, Primary Examiner. JEROME D. GOLDBERG, Assistant Examiner. 

